Produktnummer:
18717952a2d08945c39c7a02ffdf25ae6c
Themengebiete: | CLL GI tumors breast cancer endometrial cancer glioblastoma lung cancer nasopharyngeal carcinoma ovarian cancer pancreatic cancer prostate cancer |
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Veröffentlichungsdatum: | 21.12.2021 |
EAN: | 9783030805579 |
Sprache: | Englisch |
Seitenzahl: | 331 |
Produktart: | Gebunden |
Herausgeber: | Rangnekar, Vivek M. |
Verlag: | Springer International Publishing |
Untertitel: | Role in Cancer and Other Diseases |
Produktinformationen "Tumor Suppressor Par-4"
Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.

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