Produktnummer:
18472ab6bd6c3646eea2927075ba712eda
| Themengebiete: | Anticancer drug development Lead compound in drug development Total synthesis bioactive compounds cryptolepine decanolides natural product synthesis and isolation thapsigargin |
|---|---|
| Veröffentlichungsdatum: | 03.04.2021 |
| EAN: | 9783030648527 |
| Sprache: | Englisch |
| Seitenzahl: | 203 |
| Produktart: | Gebunden |
| Herausgeber: | Asakawa, Yoshinori Dirsch, Verena M. Falk, Heinz Gibbons, Simon Kinghorn, A. Douglas Liu, Ji-Kai |
| Verlag: | Springer International Publishing |
Produktinformationen "Progress in the Chemistry of Organic Natural Products 115"
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
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