Interleukin-27: Biological Properties and Clinical Application
Produktnummer:
18e345e27016274a258389cfb49e895d0f
| Autor: | Jankowski, Marek Wandtke, Tomasz |
|---|---|
| Themengebiete: | Autoimmune disorders Cancer IL-27 Immunotherapy Infectious diseases Interleukin-27 receptor Multiple sclerosis Neoplastic diseases Rheumatoid arthritis Viral infections |
| Veröffentlichungsdatum: | 23.05.2016 |
| EAN: | 9783319396620 |
| Sprache: | Englisch |
| Seitenzahl: | 86 |
| Produktart: | Kartoniert / Broschiert |
| Verlag: | Springer International Publishing |
Produktinformationen "Interleukin-27: Biological Properties and Clinical Application"
This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
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