Produktnummer:
16A3808245
| Themengebiete: | Biochemie Biologie / Zellbiologie Chemie / Biochemie Zellbiologie Zelle (biologisch) / Zellbiologie |
|---|---|
| Veröffentlichungsdatum: | 31.07.2003 |
| EAN: | 9780306478369 |
| Auflage: | 2003 |
| Sprache: | Englisch |
| Seitenzahl: | 200 |
| Produktart: | Gebunden |
| Herausgeber: | Gullberg, Donald |
| Verlag: | Springer US Springer US, New York, N.Y. |
Produktinformationen "I Domains in Integrins"
In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.
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