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Fetal Islet Transplantation

53,49 €*

Sofort verfügbar, Lieferzeit: 1-3 Tage

Produktnummer: 1836adb05e7595458e84edb60af32ec37e
Themengebiete: Antigen Diabetes Diabetes mellitus Pancreas Pancreatic Islets insulin metabolic disease tissue transplantation
Veröffentlichungsdatum: 06.01.2012
EAN: 9781461283416
Sprache: Englisch
Seitenzahl: 205
Produktart: Kartoniert / Broschiert
Herausgeber: Formby, Bent Jovanovic-Peterson, Lois Peterson, Charles M.
Verlag: Springer US
Untertitel: Implications for Diabetes
Produktinformationen "Fetal Islet Transplantation"
The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.

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