Produktnummer:
18de6ba4335e73469cb925a3d2cbd02c24
| Themengebiete: | Anti-tumor immune response Cancer-associated Tertiary Lymphoid Structures Cancer-associated fibroblasts Cancer Treatment Cancer immunotherapy Chemokines Chimeric antigen receptor Immogenic tumors |
|---|---|
| Veröffentlichungsdatum: | 22.04.2018 |
| EAN: | 9783319825281 |
| Sprache: | Englisch |
| Seitenzahl: | 199 |
| Produktart: | Kartoniert / Broschiert |
| Herausgeber: | Donnadieu, Emmanuel |
| Verlag: | Springer International Publishing |
Produktinformationen "Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy"
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
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