A Silent Threat: Exploring New Therapies for Abdominal Aortic Aneurysms
Produktnummer:
18872692d54ff74fc58c10e282b9c4fbb8
| Autor: | Mackil |
|---|---|
| Themengebiete: | Abdominal Aortic Biomarkers Clinical Trials Disease Minimally Invasive Patient Selection Risk Stratification Therapies Vascular Surgery for comparison |
| Veröffentlichungsdatum: | 05.07.2024 |
| EAN: | 9783384280077 |
| Sprache: | Englisch |
| Seitenzahl: | 204 |
| Produktart: | Kartoniert / Broschiert |
| Verlag: | tredition |
Produktinformationen "A Silent Threat: Exploring New Therapies for Abdominal Aortic Aneurysms"
Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function [16]. It is a ?bril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disul?de bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, ?brin and integrins facilitating matrix organization and cell–matrix interactions [18]. For example, ?bronectin serves as a template for proper collagen ?brillogenesis by forming a ?bril network engaged by cell surface integrins [16]. Cellular traction force causes FN to be stretched several times over its resting length [18]. As a result of such stretching, cryptic integrin-binding sites within the FN molecule is exposed resulting in pleiotropic changes in cellular behavior [18]. Hence FN acts as an extracellular mechano-regulator in addition to its role in cell migration during development. Studies have also shown the implication of FN in cardiovascular diseases and tumor metastasis
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